منابع مشابه
Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)
This review focuses on the prodrugs used in suicide gene therapy. These prodrugs need to satisfy a number of criteria. They must be efficient and selective substrates for the activating enzyme, and be metabolized to potent cytotoxins preferably able to kill cells at all stages of the cell cycle. Both prodrugs and their activated species should have good distributive properties, so that the resu...
متن کاملCommentary RNA enzyme-directed gene therapy
Inhibition of the replication of human immunodeficiency virus (HIV) through the inactivation of viral RNA with RNA enzymes (ribozymes) has been achieved in tissue culture by several groups (1-3). Three papers that highlight the continuing promise of such RNA enzymedirected gene inactivation methods have appeared recently in this journal (4-6). Yu et al. (4), using strong polymerase III promoter...
متن کاملSTEM CELL DIRECTED GENE THERAPY Barbara
1. Abstract 2. Introduction 3. Phenotype of hematopoietic stem cells 4. Sources of hematopoietic stem cells 5. Anti-HIV genes 6. Gene transfer into hematopoietic stem cells 6.1. Retroviral vectors 6.2. Lentiviral vectors 7. Gene expression 8. Clinical trials 8.1. Transfer of an anti-HIV-1 ribozyme into CD34 PBSC from HIV-1-positive adults 8.2. Transfer of an RRE decoy gene into CD34 cells from ...
متن کاملPlatelet-Targeted Gene Therapy for Hemophilia
Gene therapy is an attractive approach for disease treatment. Since platelets are abundant cells circulating in blood with the distinctive abilities of storage and delivery and fundamental roles in hemostasis and immunity, they could be a unique target for gene therapy of diseases. Recent studies have demonstrated that ectopic expression of factor VIII (FVIII) in platelets under control of the ...
متن کاملBystander or no bystander for gene directed enzyme prodrug therapy.
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the bystander effect, leads to tumour regression. Here we discuss the implications of either striving for ...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2007
ISSN: 1660-3796,1660-3818
DOI: 10.1159/000109840